Simply because of their sheer size/mass, the joints of a horse bear a tremendous load. Since force = mass x acceleration, the load on joints only increases with exercise. Canine joints also face challenges over the lifetime of a dog. Fortunately, the body is equipped with ways to balance these normal challenges to the joint and we can support efforts to do so by providing the correct supplements. The place to start is with the core ingredients described below.
The three most familiar ingredients in joint support supplements are glucosamine, chondroitin sulfate and hyaluronate (hyaluronic acid). All three are naturally occurring components of healthy joint fluid, cartilage and the connective tissue matrix of bone. In addition to being structural elements in these tissues, they also serve important homeostatic functions.
Glucosamine has been found to support the expression of enzymes synthesizing hyaluronic acid as well as components of cartilage and help maintain balance between the activity of cells which break down versus build bone. Glucosamine also facilitates a healthy balance between cytokines favoring tissue destruction and those which repair and build.
Chondroitin sulfate has a similar action in supporting a healthy anabolic (builds) catabolic (breaks down) balance. In fact, the actions of glucosamine and chondroitin complement each other.
Hyaluronic acid is a major contributor to the slippery, lubricating properties of joint fluid and it has many other functions, including the support of cell division and participating in normal clean-up and repair activities. Its presence in the joint cartilage gives it fluid holding capacity and resilience.
Methylsulfonylmethane (MSM) may assist in maintaining a balance between cytokines involved in breakdown, remodeling and repair.
Maintaining healthy joints is a challenge. Supplying basic support ingredients is a smart move.
Eleanor Kellon, VMD