All IR/EMS Horses Have Laminitis

The Equine Cushing’s and Insulin Resistance Group, now at main@ECIR.groups.io, has been in existence for almost 20 years and currently has over 11,000 members. As you might expect, many members seek out the group when their horse/pony/mini/donkey/mule becomes obviously laminitic. Others report issues confirmed by blood work but state they have never had problems with laminitis. Unfortunately, they’re wrong.

Even when not obviously laminitic, EMS horses are typically subdued,     reluctant to move, slow to turn, and appear uncomfortable

Back in 2004, Johnson et al published an article entitled Endocrinopathic Laminitis in the Horse. They described a “remodeling” of the laminae [aka lamellae] that occurs in horses with hyperinsulinemia from EMS or PPID [Cushing’s disease]. Specifically, there is lengthening and thinning of the dermal laminae which leads to weakening and predisposes to separation with resultant white line widening, rotation and sinking.  This occurs without the basement membrane damage and white blood  cell infiltration characteristic of other causes of laminitis.

Of particular interest was the report these changes are clearly visible microscopically and on radiographs in horses not showing any obvious signs of pain, inflammation or lameness.

Johnson focused on a possible role for cortisol in these changes but more recent research has clearly shown that it is insulin elevation which is to blame. Exactly how this happens is still uncertain. There is growing evidence that insulin may be acting through the IGF-1 (insulin-like growth factor) receptors to cause increased cellular proliferation.

There is some discrepancy in published studies regarding whether or not dermal and epidermal tissues in the laminae express insulin receptors. If they do, high insulin may stimulate the changes seen via those receptors. In humans, epidermal keratinocytes stimulated with insulin show the same proliferation and elongation seen in the laminae.

It has also been shown that endocrinopathic laminitis, like human metabolic syndrome, is characterized by increased levels of the potent vasoconstrictor endothelin-1 which may be causing cellular proliferation via endothelin receptors with reduction in perfusion and delivery of oxygen/glucose to the laminae.  Positive responses to herbal and amino acid support for nitric oxide generation suggest this is part of the mechanism.  Hypoxia [low oxygen tension] itself also causes migration and proliferation of keratinocytes via release of HIF-1 [hypoxia inducible factor]. The imbalance between vasodilating nitric oxide and vasoconstricting endothelin-1 is directly caused by high insulin levels within the blood vessels.

Regardless of the exact mechanism, the important thing to realize is that these changes are occurring in every horse with elevated insulin, whether they are recognized to be in pain or not. Low level lameness is easy to miss because the pain is symmetrical (no head bob). More subtle signs include less spontaneous activity, reluctance to make sharp turns, preference for soft ground, muscle tension in the forearms, back and hindquarters, more rigid head carriage (high or low) and a subdued attitude. These horses can easily be pushed over the edge into more severe pain by dietary indiscretions or even cold weather.

The good news is that meticulous attention to dietary simple carbohydrates, calories/weight, mineral balancing and additional nutritional support as needed is very successful in controlling insulin and restoring your horse’s love of life.

This is the same horse as above after being on an IR appropriate diet.

If you suspect your horse has high insulin, get a diagnosis and take correct action. Don’t allow hoof damage to progress to the point of being crippling.

Eleanor Kellon, VMD

 

About Dr. Kellon

Graduate of University of Pennsylvania Veterinary School. Owner of Equine Nutritional Solutions, www.drkellon.com, industry and private nutritional consultations, online nutritional courses. Staff Veterinary Expert at Uckele Health and Nutrition.
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2 Responses to All IR/EMS Horses Have Laminitis

  1. susan says:

    May God bless you. -Susan and Carousel.

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